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Thread: The Secret of NIMH

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    The Secret of NIMH

    Could super intelligent rodents someday escape from a research facility?

    Mice with human cells grafted into their brains outperform their normal counterparts on tests of learning and memory, according to new research. The findings, published today in the journal Cell Stem Cell, suggest that evolution of the human brain involved a major upgrade to long-neglected cells called astrocytes, and could provide a better way of testing potential treatments for neurological and psychiatric diseases.

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    Re: The Secret of NIMH

    If super-intelligent rodents escaped into the world, how would we know?

    Neurobiologist Victor Borrell, who wasn’t involved in the study, is also excited about the discovery, according to Science.

    “This study represents a major milestone in our understanding of the developmental emergence of human uniqueness.”

    Of course, the researchers needed some confirmation about the gene’s significance, and that’s where big-brained mice come in.

    In a subsequent experiment, they put the big brain gene into developing mice, doubling the size of their neocortex region. The experiment served as additional proof that ARHGAP11B is essential to growing a bigger brain.

    So… does that mean they made smarter mice with human-like cognitive abilities?

    According to Live Science, we don’t really know. The scientists did not test the rodents’ intelligence (one assumes they disposed of the mice before they got a chance to take over the world).

    Nevertheless, just having more brain cells isn’t the beginning and end of human intelligence, according to neurobiologist and study co-author Wieland Huttner. How those cells link together and how they’re formed have importance too.

    Nevertheless, Florio explained that testing lab-created big-brained mice could be a future research project.

    The full study on the big brain gene comes from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, and can be found in Science Journal here.

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    Re: The Secret of NIMH

    Perhaps the Artificial Intelligence Overlords of the future will have super-intelligent rodents as their servants?

    Researchers from Britain and Canada found that altering a single gene to block the phosphodiesterase-4B (PDE4B) enzyme, which is found in many organs including the brain, made mice cleverer and at the same time less fearful.

    "Our work using mice has identified phosphodiesterase-4B as a promising target for potential new treatments," said Steve Clapcote, a lecturer in pharmacology at Britain's Leeds University, who led the study.

    He said his team is now working on developing drugs that will specifically inhibit PDE4B. The drugs will be tested first in animals to see whether any of them might be suitable to go forward into clinical trials in humans.

    In the experiments, published on Friday in the journal Neuropsychopharmacology, the scientists ran a series of behavioral tests on the PDE4B-inhibited mice and found they tended to learn faster, remember events longer and solve complex problems better than normal mice.

    The "brainy" mice were better at recognizing a mouse they had seen the previous day, the researchers said, and were also quicker at learning the location of a hidden escape platform.

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    Re: The Secret of NIMH

    That movie ****ed me up as a child. That's all I'm saying

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    Re: The Secret of NIMH

    What could possibly go wrong from making, mice, rats, apes, etc. more intelligent?

    In the medical field, researchers believe that implanting human stem cells into other animals could give them a significant leg up when it comes to studying diseases that are difficult to study in human beings, such as Alzheimer’s, Lou Gehrig’s disease, strokes, and schizophrenia. The brain is still mostly a mystery to medical personnel and since the aforementioned diseases tend to affect patient communication, studying them in another living animal might aid in discovering how to help people affected by them.

    Chimeras could also aid scientists in cancer and AIDS studies.

    It is because of the significant uses of chimera in science that scientists are pushing back against the moratorium. The problem is that there’s a lot of things that could go wrong.

    Inserting human stem cells in an animal embryo is not an exact science.

    Stem cells introduced into the animal embryo could become brain cells, causing humanizing emotions and thoughts to develop in the creature. There is also the possibility that those stem cells could become part of the reproductive system.

    If two chimera mice mated and one had a human egg and the other had a human sperm, there could be severe consequences. Not the least of which is the possibility of a human embryo being created by the mating.

    Scientists insist that there are safe guards they could take against these possibilities, such as through use of sterilization.

    Scientists against the moratorium are scheduled to testify at the National Institutes of Health headquarters in Bethesda, Maryland, next week.

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    Re: The Secret of NIMH

    The future life on Earth will be truly amazing.

    Advances in science have allowed experts to connect tiny human brains with that of a rat.

    To do this, they created clumps of cells that behave similarly to human brains called organoids.

    Several labs have inserted those organoids into rat brains, connected them to blood vessels and successfully grown physical links.

    Medical mag Stat reported that when scientists shone a light into a rat's eye or stimulated the brain regions involved in vision, that the neurons in the implanted organoid fired up.

    It said: "That suggested the human brain tissue had become functionally integrated with the rat."

    Scientists hope this will help us understand brain injuries or treat disease.

    But experts warn that the more human brain we implant into rats, the more human-like they will become.

    Labs are implanting around three or four organoids in rats for now, but what if they added more?

    Stanford bioethicist Hank Greely said: "People are talking about connecting three or four.

    "But what if you could connect 1,000? That would be getting close to the number of cells in a mouse brain

    "At some future point, it could be that what you've built is entitled to some kind of respect."

    Scientists successfully hacked rat brains to control their limbs – making them run, freeze and turn around at the flick of a switch.

    Experts at University at Buffalo College of Arts and Sciences in New York successfully manipulated parts of the brain that control movement like freezing and spinning around, using an invisible magnetic field.

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